Identifying and characterizing functional 3′ nucleotide addition in the miRNA pathway
نویسندگان
چکیده
منابع مشابه
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هدف اصلی از این مطالعه بررسی نوع و میزان استراتژی هایی بود که دانشجویان فارسی زبان رشته ی زبان انگلیسی در حین خواندن یک متن انگلیسی به کار گرفتند. این مطالعه همچنین به بررسی تفاوت های استراتژی های مورد استفاده بین دارندگان سطح بالا و پایین درک مطلب پرداخت. نوع همبستگی بین استراتژی به کار گرفته و درک مطلب از یک سو و استراتژی به کار گرفته و انگیزه از سوی دیگر نیز در این تحقیق مورد آزمایش قرار گرف...
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1 Background and problem Analyzing functional relationships between microRNAs (miRNAs) and mRNAs is an important issue in biological process because it can give new insights into the pathogenesis mechanism of complex diseases including various cancers. Especially, miRNAs emerge recently as one of crucial molecules in post-transcriptional regulation and play critical roles in diverse processes s...
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Eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA. We investigated mR...
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ژورنال
عنوان ژورنال: Methods
سال: 2019
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2018.08.006